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Effects of nodule characteristics on sampling number and duration of thyroid fine-needle aspiration biopsy: size does not matter, but cystic degeneration ratio does

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dc.contributor.authorTÜRELİ, DERYA
dc.contributor.authorsCengic, Ismet; Tureli, Derya; Altas, Hilal; Ozden, Ferhat; Bugdayci, Onur; Aribal, Erkin
dc.date.accessioned2022-03-12T22:23:42Z
dc.date.available2022-03-12T22:23:42Z
dc.date.issued2017
dc.description.abstractBackground: Ultrasound-guided fine needle aspiration biopsy (FNAB) of thyroid nodules, though the most accurate method to rule out malignancy, still has an inherent risk of yielding non-diagnostic specimens despite immediate assessment of specimen adequacy by an on-site cytopathologist. Purpose: To evaluate the effects of nodule volume and extent of cystic degeneration on total biopsy time and number of aspirations required for obtaining an adequate specimen. Material and Methods: A total of 510 patients underwent FNAB by a single radiologist accompanied by a cytopathologist who immediately assessed each sample for specimen adequacy. All sampled nodules were single and had one maximum diameter > 10 mm. Nodule volumes and cystic degeneration ratios were calculated prior to the intervention. Aspirations were repeated until the cytological material was deemed adequate by the cytopathologist; the number of aspirations and total biopsy time were then recorded. Results: Nodule volumes did not have significant effect on neither number of aspirations necessary for achieving specimen adequacy (P > 0.05) nor total biopsy time (r = -0.148 with P = 0.001). Predominantly cystic nodules, compared to predominantly solid nodules, required more sampling per nodule (4.58 +/- 1.11 vs. 3.44 +/- 1.19 aspirations, P = 0.001) and longer total biopsy time (16.40 +/- 6.19 vs. 11.15 +/- 6.18 min, P = 0.001). Conclusion: Predominantly cystic nodules require allocation of more time for biopsy. To ensure specimen adequacy when immediate specimen evaluation by an on-site cytopathologist is not possible, four samples from predominantly solid nodules and five passes through predominantly cystic nodules are required.
dc.identifier.doi10.1177/0284185116649797
dc.identifier.eissn1600-0455
dc.identifier.issn0284-1851
dc.identifier.pubmed27235454
dc.identifier.urihttps://hdl.handle.net/11424/234519
dc.identifier.wosWOS:000394268900005
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofACTA RADIOLOGICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectThyroid nodule
dc.subjectfine needle aspiration biopsy
dc.subjectnumber of aspirations
dc.subjectcystic degeneration ratio
dc.subjectnodule size
dc.subjectspecimen adequacy
dc.subjectSPECIMEN ADEQUACY
dc.subjectBETHESDA SYSTEM
dc.subjectMANAGEMENT
dc.subjectDIAGNOSIS
dc.subjectINCIDENTALOMAS
dc.subjectCYTOPATHOLOGY
dc.subjectCYTOLOGY
dc.subjectDISEASE
dc.subjectTIME
dc.titleEffects of nodule characteristics on sampling number and duration of thyroid fine-needle aspiration biopsy: size does not matter, but cystic degeneration ratio does
dc.typearticle
dspace.entity.typePublication
local.avesis.id830e65af-de4a-4982-b701-9cf5269dbf50
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ3
oaire.citation.endPage291
oaire.citation.issue3
oaire.citation.startPage286
oaire.citation.titleACTA RADIOLOGICA
oaire.citation.volume58
relation.isAuthorOfPublication88507fe5-da7b-40c8-b5f7-83b63d66dae9
relation.isAuthorOfPublication.latestForDiscovery88507fe5-da7b-40c8-b5f7-83b63d66dae9

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