Publication: Distribution and drug resistance of pathogens isolated from patients with hematological malignancies in three-year period
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2022-09-01
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Abstract
Objective: This study aimed to retrospectively analyze the 3-year findings of bacterial and fungal pathogens isolated from infections in patients with hematological malignancies.Methods: A retrospective analysis of 158 patients with hematological malignancies treated between January 2015 and December 2017 in Okmeydanı Training and Research Hospital, Istanbul, Turkey. A total of 3374 non-consecutive blood samples (n=1954) from 158 patients, urine samples (n=1024), wound swabs (n=94), respiratory samples (n=87), and other samples (CSF, body fluids, etc.) (n=215) were collected. Results: Pathogen growth was detected in 6% (203/3374) of the samples. The most frequently isolated pathogens are coagulase-negative staphylococci (CNS, 20%), E. coli (19%), Klebsiella sp. (17%), and yeasts (16%), followed by Pseudomonas sp., Acinetobacter sp. and Enterococcus sp. (7%, 6%, and 6%, respectively). Candida species were dominant in fungal isolates (26/32; 81.2%). The most commonly detected antibiotic resistance patterns and organisms are carbapenem-resistant Acinetobacter sp. (92%), methicillin-resistant CNS (83%), carbapenem-resistant Klebsiella sp. (65%), MRSA (57%), and vancomycin-resistant Enterococci (VRE, 42%). Conclusion: Bloodstream infections accounted for more than half of all infection episodes. Periodic examination of the clinical and microbiological profiles of infections developing in patients with malignancy is essential for successful treatment management.
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Tıp, Mikrobiyoloji ve Klinik Mikrobiyoloji, Tıbbi Mikrobiyoloji, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Microbiology and Clinical Microbiology, Medical Microbiology, Health Sciences, Fundamental Medical Sciences, Klinik Tıp (MED), Yaşam Bilimleri (LIFE), Klinik Tıp, Mikrobiyoloji, TIP, GENEL & DAHİLİ, MİKROBİYOLOJİ, Clinical Medicine (MED), Life Sciences (LIFE), CLINICAL MEDICINE, MICROBIOLOGY, MEDICINE, GENERAL & INTERNAL, Genel Sağlık Meslekleri, Patofizyoloji, Temel Bilgi ve Beceriler, Değerlendirme ve Teşhis, Mikrobiyoloji (tıbbi), Dahiliye, Aile Sağlığı, Tıp (çeşitli), Genel Tıp, İmmünoloji ve Mikrobiyoloji (çeşitli), Yaşam Bilimleri, General Health Professions, Pathophysiology, Fundamentals and Skills, Assessment and Diagnosis, Microbiology (medical), Internal Medicine, Family Practice, Medicine (miscellaneous), General Medicine, Microbiology, Immunology and Microbiology (miscellaneous), Life Sciences
Citation
Arabacı Ç., Aksu M. B. , "Distribution and drug resistance of pathogens isolated from patients with hematological malignancies in three-year period", The Injector, cilt.1, sa.2, ss.47-51, 2022