Person: YOLDEMİR, AHMET TEVFİK
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YOLDEMİR
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AHMET TEVFİK
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Publication Metadata only Evaluation of sacroiliac joint MRI for pelvic venous congestion signs in women clinically suspected of sacroiliitis(SAGE PUBLICATIONS LTD, 2017) YOLDEMİR, AHMET TEVFİK; Cimsit, Canan; Yoldemir, Tevfik; Tureli, Derya; Aribal, Mustafa ErkinBackground: Pelvic congestion syndrome (PCS) is a commonly overlooked condition which is a potential cause of chronic pelvic pain. Magnetic resonance imaging (MRI) of the sacroiliac joint (SIJ) may demonstrate unexpected conditions that can mimic sacroiliitis (SI). Awareness of MRI-defined pelvic venous congestion (PVC) may help in identifying PCS, where vascular abnormality may be the sole manifestation of SIJ pain. Purpose: To detect incidental MRI-defined PVC in patients who underwent SIJ-MRI for presumed SI and define the variance of its incidence. Material and Methods: A total of 870 women who underwent SIJ-MRI were retrospectively evaluated. Incidental findings of PVC and other genitourinary and musculoskeletal system disorders were documented. Results: Of the 774 included patients, 37% demonstrated incidentally detected imaging findings related to the genitourinary system, musculoskeletal system, and PVC. The prevalence of MRI-defined PVC signs was higher in patients without SI than with SI. The prevalence of musculoskeletal disorders was higher in patients with SI whereas prevalence for genitourinary disorders was similar. Binary logistic regression analysis revealed a statistically significant correlation between SI-PVC and SI-genitourinary disorders but not between SI-musculoskeletal disorders pairs (P = 0.001, 0.001, and 0.057> 0.05). The probability of observing SI in SIJ-MRI is positively correlated with the absence of PVC or genitourinary disorders. Conclusion: Patients who underwent MRI for presumed SI demonstrated incidental PVC as well as other genitourinary and musculoskeletal findings. An awareness of these imaging findings can help identify PVC and may draw clinicians' attention to the possibility of PCS.Publication Metadata only Estrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density(TAYLOR & FRANCIS LTD, 2012) YOLDEMİR, AHMET TEVFİK; Yavuz, D. G.; Yoldemir, T.; Ozaltun, K.; Erenus, M.Objective To evaluate the frequency of the estrogen receptor (ER) gene PvuII and XbaI polymorphisms and their associations with bone mineral density (BMD) in a group of postmenopausal Turkish women. Design A total of 125 healthy postmenopausal women and 125 premenopausal healthy young women as controls were included in the study. The PvuII and XbaI polymorphisms in the ER gene were studied by the polymerase chain reaction-restriction fragment length polymorphism method. The BMD of the lumbar vertebrae and femoral neck were measured by dual-energy X-ray absorptiometry. Results The frequencies of the ER alpha PVuII genotypes PP, Pp and pp were 20%, 54.4% and 25.6% in premenopausal and 24.8%, 44.8% and 30.4% in postmenopausal women, respectively. The frequencies of the ER XbaI genotypes XX, Xx, xx were 16.8%, 48.8% and 34.4% in premenopausal and 16.8%, 48% and 35.2% in postmenopausal women, respectively. There was no difference in the frequencies of ER gene polymorphisms between premenopausal and postmenopausal women. BMD measurements were not different between ER PvuII and XbaI genotypes in premenopausal and postmenopausal women. Conclusions ER gene PvuII and XbaI polymorphisms have no major influence on bone mineral density in our group of postmenopausal women.Publication Metadata only The relationship between subjective experience of childhood abuse and neglect and depressive symptoms during pregnancy(ELSEVIER SCI LTD, 2017) YOLDEMİR, AHMET TEVFİK; Inanici, Sinem Yildiz; Inanici, Mehmet Akif; Yoldemir, A. TevfikIntroduction: Childhood abuse and neglect have devastating effects in adulthood such as depression. During pregnancy, depression's effects in women have great importance due to its serious consequences for both children and families. It is aimed to find out a relationship between childhood abuse/neglect and depression among pregnant women. Method: One-hundred-forty-four married and healthy volunteer pregnant women were recruited between February-May 2015 during their regular hospital visit. Beck Depression Inventory and Childhood Trauma Questionnaire were used to evaluate depression and childhood abuse experiences. Results: The participants' mean age was 29.37 years (SD +/- 4.71) and the average duration gestation was 28.81 weeks (SD = 5.05). Depressed women tended to get marry earlier (M = 21.07, SD = 3.47) than the non-depressed group (M = 22.55, SD = 3.36) (p = 0.012) and they had higher number of lifetime gestations (M = 3.31, SD = 2.06) than their non-depressed counterparts (M = 2.33, SD = 1.26) (p = 0.001). Each abuse and neglect score helped to predict the participants' depression scores. Conclusions: Scanning of pregnant women for both depression and childhood trauma will give change to health providers to support this vulnerable group and their prospective children. (C) 2017 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.Publication Metadata only Importance of genitourinary syndrome of menopause in the quality of life of postmenopausal women(2022-10-27) YOLDEMİR, AHMET TEVFİK; Çevik C. E. , Yoldemir A. T.Publication Metadata only Iodine status of pregnant women in a metropolitan city which proved to be an iodine-sufficient area. Is mandatory salt iodisation enough for pregnant women?(TAYLOR & FRANCIS LTD, 2016) YOLDEMİR, AHMET TEVFİK; Oral, Engin; Mathyk, Begum Aydogan; Aydogan, Berna Imge; Acikgoz, Abdullah Serdar; Erenel, Hakan; Acioglu, Hasniye Celik; Ilhan, Gokce Anik; Dane, Banu; Ozel, Aysegul; Tandogan, Bulent; Cakar, Erbil; Isci, Herman; Kayan, Basak; Aslan, Halil; Ekiz, Ali; Sancak, Seda; Celik, Ayhan; Yoldemir, Tevfik; Uzun, Ozgur; Erdogan, Murat FaikThe objective of this study was to assess the iodine status of pregnant women in a metropolitan city which was stated as iodine sufficient area after salt iodination program. This multicenter, cross-sectional study was carried out on 3543 pregnant women. Age, gestational weeks, smoking, consumption of iodized salt, dietary salt restriction, history of stillbirth, abortus and congenital malformations were questioned. Spot urine samples were analyzed for urine iodine concentration (UIC). The outcomes were: (a) median UIC in three trimesters of pregnancy and (b) frequency of ID among pregnant women. The median UIC was 73 mu g/L. The median UIC was 77 mu g/L (1-324), 73 mu g/L (1-600) and 70 mu g/L (1-1650) in three trimesters of pregnancy, respectively (p: 0.14). UIC < 50 mu g/L was observed in 36.6% (n: 1295) and UIC < 150 mu g/L was observed in 90.7% (n: 3214) of pregnant women. Only 1% (n: 34) of the pregnant women had UIC levels higher than 500 mu g/L. This study showed that more than 90% of the pregnant women in this iodine-sufficient city are facing some degree of iodine deficiency during their pregnancy. A salt iodization program might be satisfactory for the non-pregnant population, but it seems to be insufficient for the pregnant population.Publication Metadata only Delayed cord clamping in term large-for-gestational age infants: A prospective randomised study(WILEY, 2019) YOLDEMİR, AHMET TEVFİK; Vural, Irmak; Ozdemir, Hulya; Teker, Gulsen; Yoldemir, Tevfik; Bilgen, Hulya; Ozek, ErenAim To compare the post-natal effects of delayed cord clamping (DCC) and early cord clamping (ECC) in term large-for-gestational age (LGA) infants. Methods This prospective randomised study included 51 term LGA infants. The umbilical cords of these infants were clamped at 15 s in group 1 (ECC group (n = 26)) and at 60 s in group 2 (DCC group (n = 25)). Data for Apgar scores, cord blood, pH and lactate values, second haematocrit, 24th bilirubin levels, duration of hospital stay and admission to the neonatal intensive care unit (NICU) were recorded. Results The demographic characteristics of the infants in the study group were not significantly different. No statistically significant difference was observed in the post-natal haematocrit and bilirubin levels between the groups. Six infants (group 1, n = 3; group 2, n = 3) were diagnosed with polycythaemia (P = 0.79); however, these infants remained asymptomatic, and no treatment was required. One infant in each group developed hyperbilirubinemia, which required phototherapy (P = 1.00). The infant with hyperbilirubinemia in the DCC group presented with asymptomatic polycythaemia. Three neonates in the DCC group required admission to the NICU for transient tachypnoea. Conclusions No significant increase in the rate of post-natal complications of DCC in term LGA infants was observed in the study. However, before recommending DCC on a routine basis, studies with a larger sample size and long-term follow-up are required to elucidate the risks and benefits of DCC in this group of infants.Publication Metadata only Vitamin D receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density(INFORMA HEALTHCARE, 2011) YOLDEMİR, AHMET TEVFİK; Yoldemir, T.; Yavuz, D. G.; Anik, G.; Verimli, N.; Erenus, M.Objective To determine the frequency of the vitamin D receptor (VDR) gene polymorphisms BsmI, ApaI, TaqI and FokI and their associations with bone mineral density (BMD) in postmenopausal Turkish women. Design One hundred and thirty healthy postmenopausal women and 130 premenopausal healthy women acting as controls were included in the study. The BsmI, FokI, ApaI and TaqI polymorphisms in the VDR gene were studied by polymerase chain reaction-restriction fragment length polymorphism method. The BMD of the lumbar vertebrae and femur neck were measured by dual-energy X-ray absorptiometry. Comparisons between the groups were performed using the paired t-test and ANOVA. chi(2) or contingency tables were used to analyze qualitative results. Results Genotypes BB, Bb and bb occurred in premenopausal women with frequencies of 16.92%, 50% and 33.08% and in postmenopausal women with frequencies of 16.92%, 56.15% and 26.92%, respectively. Genotypes FF, Ff, ff occurred in premenopausal women with frequencies of 47.69%, 42.31% and 10% and in postmenopausal women with frequencies of 50.77%, 42.31% and 6.92%, respectively. Genotypes AA, Aa, aa occurred in premenopausal women with frequencies of 23.85%, 56.15% and 20% and in postmenopausal women with frequencies of 26.15%, 46.15% and 27.70%, respectively. Genotypes TT, Tt and tt occurred in premenopausal women with frequencies of 37.69%, 45.38% and 16.92% and in postmenopausal women with frequencies of 39.23%, 45% and 15.38%, respectively. There was no difference in the frequencies of VDR gene polymorphisms between premenopausal and postmenopausal women. BMD measurements were not different between genotypes in premenopausal and postmenopausal women. Conclusions The VDR gene BsmI, FokI, ApaI and TaqI polymorphisms have no major influence on bone mineral density in our group of postmenopausal women.Publication Metadata only Postmenopausal hyperandrogenism(TAYLOR & FRANCIS LTD) YOLDEMİR, AHMET TEVFİK; Yoldemir, T.Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from the adrenal glands and/or ovaries clinically manifested by the presence of terminal hair in androgen-dependent areas of the body, and other manifestations of hyperandrogenism such as acne and alopecia or the development of virilization. In such circumstances, physicians must exclude the possibility of rare but serious androgen-producing tumors of the adrenal glands or ovaries. Worsening of undiagnosed hyperandrogenic disorders such as polycystic ovary syndrome, congenital adrenal hyperplasia, ovarian hyperthecosis, Cushing syndrome and iatrogenic hyperandrogenism should be considered for differential diagnosis. Elevated serum testosterone not only causes virilizing effects, but also will lead to hypercholesterolemia, insulin resistance, hypertension and cardiac disease. An ovarian androgen-secreting tumor, which is diagnosed in 1-3 of 1000 patients presenting with hirsutism, comprises less than 0.5% of all ovarian tumors. Adrenal tumors, including non-malignant adenomas and malignant carcinomas, are less common than ovarian tumors but cause postmenopausal virilization. Measurement of serum testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, androstenedione and inhibin B is necessary in postmenopausal women with the complaints and signs of hyperandrogenism. Some tests to discard Cushing syndrome should also be done. After an etiological source of androgen hypersecretion has been suspected, we recommend performing magnetic resonance imaging of the adrenal glands or ovaries. Medical management with gonadotropin-releasing hormone agonist/analogues or antagonists has been reported for women who are either unfit for surgery or in whom the source of elevated testosterone is unidentified.Publication Metadata only Effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome patients(WILEY, 2018) YOLDEMİR, AHMET TEVFİK; Karadag, Cihan; Yoldemir, Tevfik; Yavuz, Dilek GogasAimThe aim of this study was to identify the effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome (PCOS) patients. MethodsSixty-seven vitamin-D-deficient (25-hydroxyvitamin D [25(OH)D] levels below 20ng/mL) PCOS patients and 54 vitamin-D-deficient non-PCOS volunteer subjects matched for age and body mass index were enrolled to this prospective study. All participants were given 50000IU/week cholecalciferol orally for 8weeks and 1500IU/day for 4weeks. Insulin sensitivity was calculated with the Matsuda insulin sensitivity index (ISI) based on an oral glucose tolerance test. Matsuda ISI, gonadal hormones (estrogen, testosterone, androstenedione), and 25(OH)D levels were studied before and at the end of the 12th week of vitamin D load. ResultsAfter vitamin D supplementation, serum androstenedione levels had decreased significantly (P=0.007) and Matsuda ISI values had increased significantly (P=0.001) in the PCOS group but no significant changes were seen in those parameters in controls. We observed positive correlations between 25(OH)D levels and Matsuda ISI (r=0.307; P< 0.01), and negative correlations between 25(OH)D levels and total testosterone (r=-0.306; P< 0.01) and androstenedione (r=-0.275; P< 0.01) levels in the PCOS group. ConclusionVitamin D supplementation increased insulin sensitivity and decreased androgen levels in vitamin-D-deficient women with PCOS but did not have any effect in vitamin-D-deficient non-PCOS women. These results may indicate the possible role of vitamin D in the complex pathogenesis of PCOS.Publication Metadata only The association of osteopenia with levels of serum 25-hydroxyvitamin D and HOMA-IR values(TAYLOR & FRANCIS LTD, 2014) YOLDEMİR, AHMET TEVFİK; Yoldemir, T.; Yavuz, D. G.Objective To determine the association of osteopenia with levels of serum 25-hydroxyvitamin D and HOMA-IR values in postmenopausal women. Methods One hundred healthy postmenopausal women were included in a cross-sectional study. Venous blood was collected after an overnight fast and 25-hydroxyvitamin D, glucose and insulin levels were measured. HOMA-IR was calculated. Bone mineral density was measured with a dual X-ray absorptiometer. Results There was no difference in serum 25-hydroxyvitamin D levels and HOMA-IR values between the two groups. A weak positive correlation between serum 25-hydroxyvitamin D levels and osteopenia was detected. Insulin resistance had a weak negative association with osteopenia. Conclusions The correlations between osteopenia and serum 25-hydroxyvitamin D levels and HOMA-IR values were weak among early postmenopausal women.