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YILMAZ ATALI, PINAR

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YILMAZ ATALI

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    PublicationOpen Access
    Cytotoxicity of Different Nano Composite Resins on Human Gingival and Periodontal Ligament Fibroblast Cell Lines: An In Vitro Study
    (MDPI, 2020-03-01) YILMAZ GÖLER, AYŞE MİNE; Kavuncu, Gamze; Yilmaz, Ayse Mine; Yilmaz, Betul Karademir; Atali, Pinar Yilmaz; Altunok, Elif Cigdem; Kuru, Leyla; Agrali, Omer Birkan
    The aim of this study is to determine the cytotoxicity of three different nano composite resins (CRs) on human gingival fibroblast (hGF) and periodontal ligament fibroblast (hPDLF) cell lines. These CRs selected were nanohybrid organic monomer-based Admira Fusion (AF), nanohybrid Bis-(acryloyloxymethyl) tricyclo [5.2.1.0.sup.2,6] decane-based Charisma Topaz (CT), and supra nano filled resin-based Estelite Quick Sigma (EQS). MTT assay was performed to assess the cytotoxicity of CRs at 24 h and one week. AF and EQS applied on hGF cells at 24 h and one week demonstrated similar cytotoxic outcomes. Cytotoxicity of CT on hGF cells at one week was higher than 24 h (p = 0.04). Cytotoxicity of CT on hGF cells was higher at 24 h (p = 0.002) and one week (p = 0.009) compared to control. All composites showed higher cytotoxicity on hPDLF cells at one week than the 24 h (AF; p = 0.02, CT; p = 0.02, EQS; p = 0.04). AF and EQS demonstrated lower cytotoxicity on hPDLF cells than the control group at 24 h (AF; p = 0.01, EQS; p = 0.001). CT was found more cytotoxic on hPDLF cells than the control (p = 0.01) and EQS group (p = 0.008) at one week. The cytotoxicity of CRs on hGF and hPDLF cells vary, according to the type of composites, cell types, and exposure time.
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    MMP3 (Rs679620) ve VDR (Rs731236) gen polimorfizmlerinin, periodontal olarak sağlikli erkek bireylerde, diş çürük lezyonu oluşumundaki etkisinin değerlendirilmesi: pilot çalışma
    (2023-01-11) ÖZMEN, SEDA; YILMAZ ATALI, PINAR; AĞRALI, ÖMER BİRKAN; TACAL ASLAN, BESTE; ULUCAN, KORKUT; Özmen S., Yılmaz Atalı P., Ağralı Ö. B., Tacal Aslan B., Yılmaz Ö. Ö., Polat T., Ulucan K.
    Amaç:Çürük oluşumu pek çok faktörün etkilediği bir süreçtir. Yapılan çalışmalar genetik faktörlerin de çürük oluşumunda rol oynadığını göstermiştir. Çalışmamızda, östrojen hormon mekanizması ve mensturasyon döngüsünün gen ekspresyon sürecini değiştirmesi sebebiyle, erkek bireylerde diş mineralizasyon sürecinde rol oynayanMMP3veVDRgenlerinde oluşan polimorfizmlerin çürük oluşumuna olan etkisinin incelenmesi amaçlanmıştır.Gereç ve Yöntem:Fakülte hastanesine başvuran 20-44 yaş aralığındaki erkek bireylerde rutin ağız içi muayenesi sonrasında; çürük, eksik ve restorasyonlu dişler (DMFT) indeksine göre tanı konulmuştur. Deney grubunu, ‘yüksek çürük risk’ (DMFT ≥ 14, n=28); kontrol grubunun ise ‘çürük lezyonu bulunmayan’ (DMFT=0, n=28) kişiler oluşturmuştur. Detaylı anamnez alınan katılımcılardan plak indeksi, sondalamada kanama ölçümü yapılmıştır.Katılımcılardan alınan kan örneklerinden DNA izolasyonları sonrasında,MMP3(rs679620)veVDR(rs731236)genotiplemesi Real-time PZR tekniği kullanılarak belirlenmiştir.Elde edilen sonuçlar istatistiksel yöntemler kullanılarakanlamlılık düzeyi p<0,05’te değerlendirilmiştir.Bulgular:Çalışmamıza katılan bireylerde sondalamada kanama derecesi %10’un altında ve DMFT=0 olan düşük risk grubundaki (kontrol) ve de sondalamada kanama derecesi %10’un altında olan yüksek risk grubundaki bireylerin (deney)MMP3veVDRpolimorfizmleri açısından kıyaslaması yapılmış ve gruplara göreMMP3dağılımları arasında istatistiksel olarak anlamlı farlılık bulunmuştur (p<0,001). Gruplara göre VDR dağılımları arasında istatistiksel olarak anlamlı farklılık bulunmamıştır (p=0,659)Sonuç:Çalışmamızın sınırları dahilinde MMP3(rs679620) gen polimorfizminin çürük oluşum üzerinde etkili;VDR(rs731236) polimorfizminin ise etkisiz olduğu sonucuna ulaşılmıştır. Katılımcı sayısının arttırılarak ileri çalışmaların yapılması gerektiği düşünülmektedir.Anahtar Kelimeler:Çürük risk değerlendirmesi, gen-çevre etkileşimi, MMP3, polimorfizm, VDR.
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    PublicationOpen Access
    Microleakage and Marginal Integrity of Ormocer/Methacrylate-Based Bulk-Fill Resin Restorations in MOD Cavities: SEM and Stereomicroscopic Evaluation
    (2023-03-01) ŞENOL, AYŞE ASLI; TARÇIN, BİLGE; KAHRAMANOĞLU, ERKUT; YILMAZ ATALI, PINAR; Şenol A. A., Karabulut Gencer B., Tarçın B., Kahramanoğlu E., Yılmaz Atalı P.
    This in vitro study aimed to compare the microleakage and marginal integrity of methacrylate/ormocer-based bulk-fill composite (BFC) restorations used in cervical marginal relocation with two different layering thicknesses in mesio-occlusal-distal (MOD) cavities exposed to thermomechanical loading. Standard MOD cavities were prepared in 60 mandibular molars and assigned into three groups: x-tra fil/AF + x-tra base/XB, Tetric N-Ceram Bulk Fill/TNB + Tetric N-Flow Bulk Fill/TFB, and Admira Fusion x-tra/AFX + Admira Fusion x-base/AFB. Each group was further divided into two subgroups (2 mm and 4 mm) based on the thickness of flowable BFCs (n = 10). The specimens were subjected to thermo-mechanical loading (240,000 cycles) and immersed in 0.2% methylene blue. Following mesiodistal sectioning, the specimens were examined under stereomicroscope (×25) and scored (0–3) for microleakage. Marginal integrity was examined using a scanning electron microscope (SEM). Descriptive statistical methods and the chi-square test were used to evaluate the data (p < 0.05). While there was no statistically significant difference in gingival cement microleakage in the XB and AFB specimens with a 4 mm thickness, microleakage was significantly increased in the TFB specimen (p = 0.604, 0.481, 0.018 respectively). A significantly higher amount of score 0 coronal microleakage was detected in the AFX2 mm + AFB4 mm compared to the TNB2 mm + TFB4 mm (p = 0.039). The SEM examination demonstrated better marginal integrity in groups with 2 mm thick flowable BFCs. Ormocer and methacrylate-based materials can be used in marginal relocation with thin layers. Keywords: bulk-fill composite; layering thicknesses; marginal relocation; microleakage; ormocer
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    Multiple diastemas closure with one-shade composite: A case report
    (2022-04-23) MANAV, AYBİKE; YILMAZ ATALI, PINAR; TÜRKMEN, CAFER; MANAV ÖZEN A., YILMAZ ATALI P., TÜRKMEN C.
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    Surface Alterations of Resin Composites: Press-on-Force-Guided Brushing Simulator with Calcium-Active Whitening- Toothpastes
    (2023-07-03) SEVER, DENİZ MELTEM; DOĞU KAYA, BENGÜ; MANAV, AYBİKE; ALKAN, ELİF; YILMAZ ATALI, PINAR; KORKUT, BORA; TAĞTEKİN, DİLEK; SEVER D. M., DOĞU KAYA B., MANAV ÖZEN A., Öztürk S., ALKAN E., YILMAZ ATALI P., KORKUT B., TAĞTEKİN D.
    Introduction: The purpose was to investigate the surface roughness and the color changes of nanohybrid and microhybrid resin composites subjected to calcium active whitening toothpastes with different RDA values through a novel Press-on Force-Guided (PFG) Brushing Simulator. Material and Methods: Twenty-eight disc-shape samples (10x2mm) of a nanohybrid (Herculite, Kerr) and a microhybrid (Z250, 3M) composites were prepared and randomly divided into 4 subgroups (n=7). The samples were polymerized with a LED-curing unit with an irradiance of 1000 mW/cm2 (Valo Cordless, Ultradent). Finishing and polishing procedures were performed with 2 fine grits of Sof-Lex Discs (3M). Samples were stored in distilled water at 37°C for 24 hours. Composite samples were brushed with a medium-bristle toothbrush (ROCS Pro 5940, ROCS) using the PFG brushing simulator (Marmara University, Turkey) for 60.000 strokes (correspondence to 6 years clinically) in a slurry containing toothpaste with 120 RDA (Ca Active Whitening, ROCS) and 70 RDA (Electro Whitening, ROCS) under 300-320g load (200 strokes/min). In particular, surface roughness (Ra) and color change (ΔE) were investigated utilizing profilometer (MarSurf PS 10, Mahr) and spectrophotometer (Easy-Shade-5, VITA). Analysis of variance was used for repeated measurements; Bonferroni test was used for pairwise comparisons. The level of significance was set at p<0.05. Results: After brushing Ra values did not show a significant difference (p>0.05) except Herculite group brushed with Electro whitening (p=0.05) which showed the most roughness change (36.99%). There is a significant difference between Herculite (1.163±0.701) and Z250 (0.400±0.154) in Ra values after electro-whitening brushing (p=0.002). No significant color change was observed in any group, regardless of composite or tooth-paste type (p>0.05). ΔE values of Herculite (1.007±0.463; 1.100±0.452) and Z250 (1.558±0.618; 1.196±0.835) brushed with Ca Active Whitening and Electro Whitening toothpastes were less than 1.8 respectively. Conclusion: Tooth brushing with Ca active whitening toothpastes (different RDA values) affected differently on the surface roughness of Herculite and Z250 due to their filler and resin composition, but there is no effect on color. Keywords: brushing simulator, resin composite, whitening toothpaste, surface roughness, color change
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    Elektrikli ve manuel diş fırçalarının dental plağın uzaklaştırılmasında etkinliğinin ağız içi görüntülemesistemleri ile klinik değerlendirilmesi
    (2022-10-19) ALKAN, ELİF; TAĞTEKİN, DİLEK; YILMAZ ATALI, PINAR; KORKUT, BORA; Kayhan A., ALKAN E., TAĞTEKİN D., YANIKOĞLU F., YILMAZ ATALI P., KORKUT B., ILGIN C.
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    Effect of the use of remineralization agents before resin infiltration on the treatment of initial enamel lesions: OCT, ultrasound, and SEM evaluation
    (2023-06-11) MANAV, AYBİKE; DOĞU KAYA, BENGÜ; YILMAZ ATALI, PINAR; ALKAN, ELİF; TAĞTEKİN, DİLEK; MANAV ÖZEN A., DOĞU KAYA B., YILMAZ ATALI P., SARIALİOĞLU GÜNGÖR A., ALKAN E., DALKILIÇ E., TAĞTEKİN D., TÜRKMEN C.
    Aim: It was aimed to investigate the effect of using remineralizing agent before resin infiltration application on the treatment of initial enamel lesions with OCT (Optical Coherence Tomography), Ultrasound and SEM (Scanning Electromicroscope). Materials and Methods: 80 enamel samples were kept in the demineralization solution (pH 4.5, 37°C) for 96 hours. Demineralized enamel samples will be randomly divided into 8 groups (n=10) including a remineralizing agent(Toothmousse/GC, Remin Pro/VOCO, Medical Mineral Gel/ROCS), resin infiltration (ICON/DMG), and a combined treatment of both. All remineralization agents were applied in remineralization cycle 2 times a day for 1 week.Measurements made from the enamel samples at the baseline, after demineralization and remineralization procedures evaluated with the OCT (Topcon3D OCT-1 Maestro) and ultrasonic system (Novascope 4500:NDT) lesion depths were measured. The sample surfaces were examined under SEM/EDS (Zeiss EVO-MA10) at x1000, 2500, 5000 and 10000. Data were analyzed in R program with WRS2. Two-way Robust Anova, Benferroni Test, and ICC (Intra-Class Correlation Coefficient) was used to examine the agreement between measurements. Significance level was set at p<0.05. Results: There was no statistical difference between the groups in OCT (p=0.884) and Ultrasound (p=0.051) median values after the protocols. In both measurement methods, the effect of remineralization treatments was statistically significant for lession depth (p<0.01). OCT median values were 104.01 in baseline, 144.78 in post-demineralization, and 90.5 in post-remineralization. Ultrasound median values were 1.34 in baseline, 1.1 in postdemineralization, and 2.36 inpost-remineralization. The highest ultrasound median value was obtained in the Remin Pro+ICON after remineralization (2.67), while the lowest value was obtained after demineralization (1.04). As a result of EDS analysis, the lowest Ca ratio (%atomic) was observed on the grup 5-ICON applied enamel surface (9.35). Conclusion: Although there is no significant difference between the groups, all groups were found efficient for remineralization treatments according to OCT, Ultrasound, and SEM/EDS analysis.
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    Mmp3 (rs679620) ve vdr (rs731236) genleri̇nde oluşan poli̇morfi̇zmleri̇n gen-çevre etki̇leşimleri̇ İle çürük ri̇sk değerlendi̇rmesi̇ üzeri̇ne olan etki̇leri
    (2022-10-19) YILMAZ ATALI, PINAR; AĞRALI, ÖMER BİRKAN; TACAL ASLAN, BESTE; AKSU, MEHMET BURAK; ULUCAN, KORKUT; ÖZMEN, SEDA; Özmen S., Yılmaz Atalı P., Ağralı Ö. B. , Tacal Aslan B., Aksu M. B. , Ulucan K.
    MMP3(rs679620) VEVDR(rs731236) GENLERİNDE OLUŞANPOLİMORFİZMLERİN GEN-ÇEVRE ETKİLEŞİMLERİ İLE ÇÜRÜK RİSK DEĞERLENDİRMESİ ÜZERİNE OLAN ETKİLERİSeda Özmen,Pınar Yılmaz Atalı, Ömer Birkan Ağralı, Becte Tacal Aslan, Özlem Özge Yılmaz,Tolga Polat, Mehmet Burak Aksu, Korkut UlucanAmaç:Günümüzde yapılan çürük risk modellerinde çoklu değişkenler eklenmiş ve özellikle gen-çevre etkileşimi incelenmiştir. Çalışmamızın amacı;VDRveMMP3genlerinde meydana gelen gen polimorfizmlerin etkilerinin değerlendirilip çürük risk modellemesi üzerine olan etkilerinin incelenmesidir.Gereç ve Yöntem:Çalışma populasyonu, fakülte hastanesine başvuran 20-44 yaş aralığındaki erkek bireylerde rutin ağız içi muayenesi sonrasında çürük, eksik ve restorasyonlu dişler (DMFT) indeksine göre tanı konulan ‘yüksek çürük risk’(DMFT ≥ 14) ve düşük çürük risk’(DMFT£5) olarak 2 gruptan oluşturulmuştur (n=160). Detaylı anamnez alınan katılımcılardan plak indeksi, gingival indeks sondalamada kanama, sondalama derinliği, klinik ataşman seviyesi ve tükürük tamponlama kapasitesi, tükürük streptekok mutans (SM) ve laktobasil (LB) sayısı ölçülmüştür.Katılımcılardan alınan kan örneklerinden DNA izolasyonları sonrasında,MMP3(rs679620)veVDR(rs731236)genotiplemesi ise Real-time PZR tekniği kullanılarak belirlenmiştir.Elde edilen sonuçlar istatistiksel yöntemler kullanılarakanlamlılık düzeyi p<0,05’te değerlendirilmiştir.Bulgular:Gruplar arası plak indeksi, gingival indeks, sondalama derinliği, klinik ataşman seviyesi, sondalamada kanama, tükürük akış hızı, tükürük tamponlama kapasitesi ve tükürük SM ve LB sayısı faktörleri arasında anlamlı düzeyde fark bulunmuştur (p<0,001). Çevresel risk faktörlerinde sosyoekonomik durum, diş fırçalama sıklığı, koruyucu diş tedavisine yönelik uygulama durumları açısından gruplar arasında anlamlı düzeyde fark tespit edilmiştir (p<0,001).MMP3rs679620 polimorfizminin de çürük risk belirlemesinde etkili olduğu (p<0,001);VDRpolimorfizminin ise etkili olmadığı (p=0,862) tespit edilmiştir.DMFT’ ye etki eden değişkenlerin incelenmesinde Adımsal Regresyon Analizi yapılarak model 7 adımda incelenmiştir ve modeller istatistiksel olarak anlamlı bulunmuştur (p<0,001).Çevresel risk faktörü olarak plak indeksi, sondalamada kanama, şekerli ara öğün tüketim sıklığı, tükürük tamponlaması,MMP3rs679620 gen polimorfizminin içerenModel 5 DMFT’ nin %58’ini açıklamıştır.Sonuç:Çürük risk modelinde; plak indeksi, sondalamada kanama, şekerli ara öğün tüketim sıklığı, tükürük tamponlaması,MMP3rs679620 gen polimorfizminin çevresel risk faktörü olarak modelde yer alması, bireylerin risk gruplarının belirlenmesinde etkili olacaktır.Anahtar Kelimeler:Çürük risk değerlendirmesi, gen-çevre etkileşimi,MMP3, Polimorfizm, VDR.
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    Thermal, spectral, and surface properties of LED light-polymerized bulk fill resin composites
    (WALTER DE GRUYTER GMBH, 2015) YILMAZ ATALI, PINAR; Piskin, Mehmet Burcin; Atali, Pinar Yilmaz; Figen, Aysel Kanturk
    The aim of this study was to evaluate the thermal, spectral, and surface properties of four different bulk fill materials - SureFil SDR (SDR, Dentsplay DETREY), QuixFil (QF, Dentsplay DETREY), X-tra base (XB, Voco) X-tra fil (XF, Voco) - polymerized by light-emitting diode (LED). Resin matrix, filler type, size and amount, and photoinitiator types influence the degree of conversion. LED-cured bulk fill composites achieved sufficient polymerization. Scanning electron microscope (SEM) analysis revealed different patterns of surface roughness, depending on the composite material. Bulk fill materials showed surface characteristics similar to those of nanohybrid composites. Based on the thermal analysis results, glass transition (T-g) and initial degradation (T-i) temperatures changed depending on the bulk fill resin composites.
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    Class IV composite restorations of central Incisors: One-shade vs multishade, case series
    (2022-04-23) DOĞU, BENGÜ; TARÇIN, BİLGE; YILMAZ ATALI, PINAR; DOĞU B., YILMAZ ATALI P., TARÇIN B.
    Aim: Fractures or deformities are common in central incisors. The aim of this case series was to compare and evaluate incisal/class IV restorations using 3 different composites: OptiShade (Kerr), Amaris (Voco), and Ceram-X Duo (Dentpsly-Sirona). Case Description: 3 patients with the complaint of fractures on their anterior teeth were applied to the clinics of Restorative Dentistry Department (Case1 18-year-old female, Case 2 20-year-old female, and Case 3 17-yearold male). Following radiographic and clinical examinations, enamel fracture was detected in the incisal 1/3 of the central incisors and it was decided to perform direct composite resin restorations (CRR) as the treatment plan. 37% orthophosphoric acid (Kerr) was used in selective-etch mode. 3 different universal adhesive agents (OptiBond Universal, Kerr; Futurabond U, Voco; and Prime&Bond Universal, Dentsply-Sirona) were applied to the cavities according to manufacturer’s instructions. CRRs were completed with nano-hybrid (Amaris TL and D2, Voco), one-shade (OptiShade Light and Medium, Kerr), and ceramic reinforced (Ceram-X Duo D2 and E1, Denstply-Sirona) composites using incremental technique. Valo-Cordless (Ultradent) was used for polimerisation with 1000 mW/cm2. Finishing and polishing procedures were performed with polishing discs (Bisco) and Twist Dia (Kuraray) polishing wheels. Patients were recalled at 1 and 3-months for clinical evaluation and scores according to FDI criteria. Results: The esthetic, functional and biological evaluation of the restorations according to the FDI criteria in 1 and 3-months follow-up were scored as 1. Discussion: One shade universal composite provide advantage in color selection for the clinician, however composites with different contents and brands vary in opacity, color, and brightness. Considering the esthetic expectation of the patients and the longevity of class IV CRR, the material should be selected considering the shape, color and fracture line of the tooth structure and the optic properties of the material.