Publication: Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic
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Date
2015
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ELSEVIER SCIENCE BV
Abstract
Bacillus subtilis has the capacity to produce more than two dozen bioactive compounds with an amazing variety of chemical structures. Among them, bacilysin is a non-ribosomally synthesized dipeptide antibiotic consisting of L-alanine residue at the N terminus and a non-proteinogenic amino acid, L-anticapsin, at the C terminus. In spite of its simple structure, it is active against a wide range of bacteria and fungi. As a potent antimicrobial agent, we briefly review the biochemistry and genetics as well as the regulation of bacilysin biosynthesis within the frame of peptide pheromones-based control of secondary activities. Biological functions of bacilysin in the producer B. subtilis beyond its antimicrobial activity as well as potential biotechnological use of the biosynthetic enzyme L-amino acid ligase (Lal) are also discussed.
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Keywords
BACTERIUM BACILLUS-SUBTILIS, AMINO-ACID LIGASE, PEPTIDE ANTIBIOTICS, COMPETENCE DEVELOPMENT, INSERTIONAL MUTATIONS, STAPHYLOCOCCUS-AUREUS, STATIONARY-PHASE, QUORUM RESPONSE, SPORULATION, ANTICAPSIN