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Protective Effects of Momordica charantia (Bitter Melon) against Metho-trexate-induced Kidney Damage

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dc.contributor.authorÖZBEYLİ, DİLEK
dc.contributor.authorsMACİT Ç., ÖZBEYLİ D., Cevik O., Cetin M., Sener G., Özkan S.
dc.date.accessioned2023-06-12T10:31:24Z
dc.date.available2023-06-12T10:31:24Z
dc.date.issued2023-01-01
dc.description.abstractBackground: Methotrexate is a cytotoxic chemotherapeutic agent that has severe side ef-fects, such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been shown to have antioxidant, antidiabetic, and anti-inflammatory properties. Methods: 24 Sprague Dawley male rats were divided into three experimental groups (8 rats in each): Control (C); Methotrexate (MTX); and Methotrexate plus Momordica charantia (MTX+MC). All rats were fed ad libitum and tap water. Methotrexate was administered at 20 mg/kg intraperitoneally as a single dose. In the MTX+MC group, MC was administered at a dose of 50mg/kg for 5 days orally. At the end of the 5th day, the rats were decapitated and kidney samples were taken to analyze glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), 8-hydroxy-2\"-deoxyguanosine (8-OHdG) and caspase-3 activity. Data was analyzed with GraphPad Prism 5.0. Results: Findings showed that while there was a significant increase in MDA, MPO, 8-OHdG levels, and an essential reduction in GSH levels in the MTX-treated group when compared with the control group, bitter melon treatment significantly reversed MDA, MPO, and 8-OHdG levels (p< 0.001). GSH level elevation was observed in the MTX-MC group when compared to the MTX-treated group (p< 0.001). Conclusion: This study showed that bitter melon is thought to have a protective effect against kidney damage caused by methotrexate. With future studies, we believe that the use of bitter melon extract as a protective agent in kidney damage caused by drug-induced oxidative damage will bring an innova-tive approach to treatment.
dc.identifier.citationMACİT Ç., ÖZBEYLİ D., Cevik O., Cetin M., Sener G., Özkan S., "Protective Effects of Momordica charantia (Bitter Melon) against Metho-trexate-induced Kidney Damage", Current Drug Therapy, cilt.18, sa.3, ss.231-236, 2023
dc.identifier.doi10.2174/1574885518666230112110246
dc.identifier.endpage236
dc.identifier.issn1574-8855
dc.identifier.issue3
dc.identifier.startpage231
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85160608207&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/290187
dc.identifier.volume18
dc.language.isoeng
dc.relation.ispartofCurrent Drug Therapy
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectLife Sciences (LIFE)
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectkidney
dc.subjectmethotrexate
dc.subjectMomordica charantia
dc.subjectnephrotoxicity
dc.subjectoxidative damage
dc.subjectprotective effect
dc.titleProtective Effects of Momordica charantia (Bitter Melon) against Metho-trexate-induced Kidney Damage
dc.typearticle
dspace.entity.typePublication
local.avesis.id0499b1d7-096f-4675-bd81-404a4f6e5362
local.indexed.atSCOPUS
relation.isAuthorOfPublication4681bb67-e40b-4cf0-8154-5472237f2325
relation.isAuthorOfPublication.latestForDiscovery4681bb67-e40b-4cf0-8154-5472237f2325

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