Publication:
Protective role of progesterone on lung injury induced by ischemia reperfusion of the lower limbs

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dc.contributor.authorAK, ESİN
dc.contributor.authorOKTAY, NİHAL ŞEHKAR
dc.contributor.authorÖZBEYLİ, DİLEK
dc.contributor.authorAK, KORAY
dc.contributor.authorsAK E., OKTAY N. Ş., ÖZBEYLİ D., Muhan A., AK K.
dc.date.accessioned2023-01-16T10:28:48Z
dc.date.available2023-01-16T10:28:48Z
dc.date.issued2022-01-01
dc.description.abstractObjective: Remote lung injury is one of the most challenging issues in patients undergoing ischemia reperfusion (IR) injury of the lower limbs. We examined the role of progesterone (PG) on the remote injury of the lungs seen after IR of the lower limbs. Methods: Eighteen male Sprague Dawley rats were divided into three groups. (1) Control: rats had only two physiological saline injections intraperitoneally (i.p.) 2 h apart under general anesthesia. (2) IR: underwent 2 h tourniquet induced ischemia for both lower limbs followed by 2 h of reperfusion. Animals were injected with physiological saline (i.p.) before both ischemia and reperfusion. (3) IR + PG: rats underwent the same IR protocol as the IR group and were injected with PG (16 mg/kg, i.p.) before both ischemia and reperfusion. After reperfusion, rats were sacrificed, and lung tissues were taken out for histopathologic and biochemical analyses. Results: In IR + PG group, tissue levels of malondialdehyde and nitric oxide decreased significantly compared with the IR group (p<0.01). Similarly, glutathione level and superoxide dismutase and glutathione S-transferase activities significantly increased in the IR + PG group than in the IR group (p<0.05, p<0.01, and p<0.05, respectively). In light microscopy, reduced inflammatory cell infiltration, amelioration in alveolar structure, and mild vascular congestion in the parenchyma were seen in the IR + PG group. A significant improvement in histopathologic score was seen in the IR + PG group compared with the IR group (p<0.001). Conclusion: PG might be effective in attenuating remote injury of the lung in lower body IR via its antioxidant function
dc.identifier.citationAK E., OKTAY N. Ş., ÖZBEYLİ D., Muhan A., AK K., "Protective Role of Progesterone on Lung Injury Induced by Ischemia Reperfusion of the Lower Limbs", Southern Clinics of Istanbul Eurasia, cilt.33, sa.3, ss.320-325, 2022
dc.identifier.doi10.14744/scie.2022.57873
dc.identifier.endpage325
dc.identifier.issn2587-0998
dc.identifier.issue3
dc.identifier.startpage320
dc.identifier.urihttp://dx.doi.org/10.14744/scie.2022.57873
dc.identifier.urihttps://hdl.handle.net/11424/285350
dc.identifier.volume33
dc.language.isoeng
dc.relation.ispartofSouthern Clinics of Istanbul Eurasia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectschemia
dc.subjectlower limb
dc.subjectlung
dc.subjectremote organ injury
dc.subjectreperfusion
dc.titleProtective role of progesterone on lung injury induced by ischemia reperfusion of the lower limbs
dc.typearticle
dspace.entity.typePublication
local.avesis.id42a53f4b-1d98-44d8-854c-1d6a6d34c878
local.indexed.atTRDIZIN
relation.isAuthorOfPublication26206430-ce02-4950-b9ad-f8add11fdfc2
relation.isAuthorOfPublicationeaf67f2d-ce76-4abc-afe1-ec62645dfe87
relation.isAuthorOfPublication4681bb67-e40b-4cf0-8154-5472237f2325
relation.isAuthorOfPublication14a26caf-f6e3-4f46-9cf6-cdbc53973ee6
relation.isAuthorOfPublication.latestForDiscovery26206430-ce02-4950-b9ad-f8add11fdfc2

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