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A review on the mechanistic details of OXA enzymes of ESKAPE pathogens

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dc.contributor.authorSARIYAR AKBULUT, BERNA
dc.contributor.authorÖZBEK SARICA, PEMRA
dc.contributor.authorsAvci F. G., Tastekil I., Jaisi A., ÖZBEK SARICA P., SARIYAR AKBULUT B.
dc.date.accessioned2023-07-25T08:28:19Z
dc.date.available2023-07-25T08:28:19Z
dc.date.issued2023-01-01
dc.description.abstractThe production of beta-lactamases is a prevalent mechanism that poses serious pressure on the control of bacterial resistance. Furthermore, the unavoidable and alarming increase in the transmission of bacteria producing extended-spectrum beta-lactamases complicates treatment alternatives with existing drugs and/or approaches. Class D beta-lactamases, designated as OXA enzymes, are characterized by their activity specifically towards oxacillins. They are widely distributed among the ESKAPE bugs that are associated with antibiotic resistance and life-threatening hospital infections. The inadequacy of current beta-lactamase inhibitors for conventional treatments of \"OXA\" mediated infections confirms the necessity of new approaches. Here, the focus is on the mechanistic details of OXA-10, OXA-23, and OXA-48, commonly found in highly virulent and antibiotic-resistant pathogens Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterobacter spp. to describe their similarities and differences. Furthermore, this review contains a specific emphasis on structural and computational perspectives, which will be valuable to guide efforts in the design/discovery of a common single-molecule drug against ESKAPE pathogens.
dc.identifier.citationAvci F. G., Tastekil I., Jaisi A., ÖZBEK SARICA P., SARIYAR AKBULUT B., "A review on the mechanistic details of OXA enzymes of ESKAPE pathogens", PATHOGENS AND GLOBAL HEALTH, cilt.117, sa.3, ss.219-234, 2023
dc.identifier.doi10.1080/20477724.2022.2088496
dc.identifier.endpage234
dc.identifier.issn2047-7724
dc.identifier.issue3
dc.identifier.startpage219
dc.identifier.urihttps://www.tandfonline.com/doi/epdf/10.1080/20477724.2022.2088496?needAccess=true&role=button
dc.identifier.urihttps://hdl.handle.net/11424/291542
dc.identifier.volume117
dc.language.isoeng
dc.relation.ispartofPATHOGENS AND GLOBAL HEALTH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectParazitoloji
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectSosyoloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectParasitology
dc.subjectSocial Sciences and Humanities
dc.subjectSociology
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectBiochemistry
dc.subjectNatural Sciences
dc.subjectKAMU, ÇEVRE VE İŞ SAĞLIĞI
dc.subjectSosyal Bilimler Genel
dc.subjectSosyal Bilimler (SOC)
dc.subjectPARAZİTOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTROPİKAL TIP
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
dc.subjectSOCIAL SCIENCES, GENERAL
dc.subjectSocial Sciences (SOC)
dc.subjectPARASITOLOGY
dc.subjectBIOLOGY & BIOCHEMISTRY
dc.subjectLife Sciences (LIFE)
dc.subjectTROPICAL MEDICINE
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectİş Sağlığı ve Terapisi
dc.subjectGüvenlik Araştırması
dc.subjectSağlık (sosyal bilimler)
dc.subjectGenel Sosyal Bilimler
dc.subjectFarmasötik bilim
dc.subjectHalk, Çevre ve İş Sağlığı
dc.subjectEpidemiyoloji
dc.subjectBiyokimya (tıbbi)
dc.subjectSosyal Bilimler ve Beşeri Bilimler
dc.subjectOccupational Therapy
dc.subjectSafety Research
dc.subjectHealth (social science)
dc.subjectGeneral Social Sciences
dc.subjectPharmaceutical Science
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectEpidemiology
dc.subjectBiochemistry (medical)
dc.subjectSocial Sciences & Humanities
dc.subjectB-lactamase
dc.subjectOXA-10
dc.subjectOXA-23
dc.subjectOXA-48
dc.subjectESKAPE bugs
dc.subjectD BETA-LACTAMASES
dc.subjectEXTENDED-SPECTRUM VARIANT
dc.subjectCLASS D CARBAPENEMASES
dc.subjectACINETOBACTER-BAUMANNII
dc.subjectKLEBSIELLA-PNEUMONIAE
dc.subjectCLASS-A
dc.subjectCRYSTAL-STRUCTURE
dc.subjectSTRUCTURAL BASIS
dc.subjectIMIPENEM-RESISTANCE
dc.subjectESCHERICHIA-COLI
dc.subjectΒ-lactamase
dc.titleA review on the mechanistic details of OXA enzymes of ESKAPE pathogens
dc.typearticle
dspace.entity.typePublication
local.avesis.id6bea76d1-6386-4fbc-951d-29cee6c216f5
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationa9f127d3-8332-44dd-a532-34f3ef20bdb5
relation.isAuthorOfPublication23dff805-7adb-4a47-9412-24e5d1012e63
relation.isAuthorOfPublication.latestForDiscoverya9f127d3-8332-44dd-a532-34f3ef20bdb5

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