Publication: Myrtus communis subsp. communis improved cognitive functions in ovariectomized diabetic rats
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2020
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Abstract
Aim: The purpose of this study was to investigate the possible effects of Myrtus communis subsp. communis (MC) on cognitive impairment in ovariectomized diabetic rats. Material and method: Female Sprague-Dawley rats were divided into 5 groups consisting of 15 rats each; Control (C), Diabetes (D), Ovariectomy and diabetes (OVX + D), Ovariectomy, diabetes and donepezil (OVX + D + Don), Ovariectomy, diabetes and Myrtus communis subsp. communis (OVX + D + MC). Blood glucose measurements were made at the beginning and end of the experiments. The animals underwent the novel object recognition test (NORT) and their performance was evaluated. In hippocampal tissues; amyloid beta (A beta) and neprilysin levels, acetylcholinesterase (AChE), and choline acetyltransferase (ChAT) activities, polysialylated neural cell adhesion molecule (PSA-NCAM), alpha 7 subunit of neuronal nicotinic acetylcholine receptor (alpha 7-nAChR) and brain derived neurotrophic factor (BDNF) gene expressions were examined. Results: Animals with ovariectomy and diabetes showed increased levels of blood glucose, AChE activity and A beta levels, and decreased neprilysin levels, ChAT activity, alpha 7-nAChR, PSA-NCAM and BDNF gene expressions in parallel with a decrease in NORT performance score. On the other hand, in the MC-treated OVX + D group, there was a significant decrease observed in blood glucose levels and AChE activities while there was improvement in NORT performances and an increase in hippocampal ChAT activity, neprilysin levels, alpha 7-nAChR, PSA-NCAM and BDNF expressions. Conclusion: These results suggest that MC extract could improve cognitive and neuronal functions with its anticholinesterase and antihyperglycemic properties.
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Postmenopausal diabetes, Myrtle, Cognitive impairment, Amyloid beta, ALZHEIMERS-DISEASE, IN-VITRO, A-BETA, BRAIN, L., ESTROGEN, EXTRACTS, INSULIN, LEAVES, MEMORY