Publication:
Myrtus communis subsp. communis improved cognitive functions in ovariectomized diabetic rats

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsYaman, Beril Kadioglu; Cevik, Ozge; Yalman, Kubra; Ertas, Busra; Sen, Ali; Sener, Goksel
dc.date.accessioned2022-03-12T22:43:28Z
dc.date.available2022-03-12T22:43:28Z
dc.date.issued2020
dc.description.abstractAim: The purpose of this study was to investigate the possible effects of Myrtus communis subsp. communis (MC) on cognitive impairment in ovariectomized diabetic rats. Material and method: Female Sprague-Dawley rats were divided into 5 groups consisting of 15 rats each; Control (C), Diabetes (D), Ovariectomy and diabetes (OVX + D), Ovariectomy, diabetes and donepezil (OVX + D + Don), Ovariectomy, diabetes and Myrtus communis subsp. communis (OVX + D + MC). Blood glucose measurements were made at the beginning and end of the experiments. The animals underwent the novel object recognition test (NORT) and their performance was evaluated. In hippocampal tissues; amyloid beta (A beta) and neprilysin levels, acetylcholinesterase (AChE), and choline acetyltransferase (ChAT) activities, polysialylated neural cell adhesion molecule (PSA-NCAM), alpha 7 subunit of neuronal nicotinic acetylcholine receptor (alpha 7-nAChR) and brain derived neurotrophic factor (BDNF) gene expressions were examined. Results: Animals with ovariectomy and diabetes showed increased levels of blood glucose, AChE activity and A beta levels, and decreased neprilysin levels, ChAT activity, alpha 7-nAChR, PSA-NCAM and BDNF gene expressions in parallel with a decrease in NORT performance score. On the other hand, in the MC-treated OVX + D group, there was a significant decrease observed in blood glucose levels and AChE activities while there was improvement in NORT performances and an increase in hippocampal ChAT activity, neprilysin levels, alpha 7-nAChR, PSA-NCAM and BDNF expressions. Conclusion: These results suggest that MC extract could improve cognitive and neuronal functions with its anticholinesterase and antihyperglycemic properties.
dc.identifier.doi10.1016/j.gene.2020.144616
dc.identifier.eissn1879-0038
dc.identifier.issn0378-1119
dc.identifier.pubmed32222531
dc.identifier.urihttps://hdl.handle.net/11424/236327
dc.identifier.wosWOS:000532826900004
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofGENE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPostmenopausal diabetes
dc.subjectMyrtle
dc.subjectCognitive impairment
dc.subjectAmyloid beta
dc.subjectALZHEIMERS-DISEASE
dc.subjectIN-VITRO
dc.subjectA-BETA
dc.subjectBRAIN
dc.subjectL.
dc.subjectESTROGEN
dc.subjectEXTRACTS
dc.subjectINSULIN
dc.subjectLEAVES
dc.subjectMEMORY
dc.titleMyrtus communis subsp. communis improved cognitive functions in ovariectomized diabetic rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id54b8df99-3756-4120-9bbb-6582182a1f43
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber144616
local.journal.numberofpages8
local.journal.quartileQ2
oaire.citation.titleGENE
oaire.citation.volume744
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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