Publication: Twenty years’ experience in the management of childhood germ cell tumors
No Thumbnail Available
Date
2017-09-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background/Objectives: Germ cell tumors (GCT) account
for 2-3% of childhood tumors. It is most commonly seen
under 3 years and over 12 years old. GCTs are most commonly localized in the gonads. We have examined our
patients who diagnosed and treated with GCT at our center
retrospectively.
Design/Methods: Sixty two children and adolescence who
were diagnosed and treated with GCT at our center between
1996 and 2016 analyzed retrospectively.
Results: The patients age ranged between 5 days to 17 years.
Thirty-five of patients were girls (57%) and 27 were boys
(43%). The most common tumor localization with 29(47%)
patients was gonads. Sixteen patients (25,8%) had metastatic
disease at presentation. The most common histologic subtype was mature teratoma with 14 (22%) patients and 14
patients (22%) with yolk sac tumor. Alpha-fetoprotein (AFP)
was elevated in 29 (46%) of cases whereas beta-human
chorionic gonadotropin (𝛽-hCG) was elevated in only 4
(4%) of cases. Twenty-two cases (35%) were treated with
total surgical resection and they didn't receive chemotherapy. Six patients (10%) received radiotherapy in addition
to surgery and chemotherapy. Thirty-three patients (53,3 %)
received BEP (bleomycin, etoposide, cisplatin) as a first line
chemotherapy. During the follow up 6 (10 %) patients had
relapsed. Five years overall survival rate of our patients was
95%, retrospectively.
Conclusions: Germ cell tumors have favorable outcome in
children. These tumors can be cured with surgical resection
followed by cisplatin-based chemotherapy and radiotherapy
for selected patients. As a result of our own data analysis, it
has been found that our survival rates are similar to current
literature data.
Description
Keywords
Citation
ŞENAY R. E., DOĞRU Ö., TOKUÇ A. G., EKER N., YILMAZ B., BERK B., \"Twenty Years’ Experience in the Management of Childhood Germ Cell Tumors\", 49th CONGRESS OF THE INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY (SIOP), Amerika Birleşik Devletleri, 12 Ekim 2017