Publication: Twenty years’ experience in the management of childhood germ cell tumors
| dc.contributor.author | TRUE, ÖMER | |
| dc.contributor.author | TOKUÇ, AYŞE GÜLNUR | |
| dc.contributor.author | EKER, NURŞAH | |
| dc.contributor.authors | ŞENAY R. E., DOĞRU Ö., TOKUÇ A. G., EKER N., YILMAZ B., BERK B. | |
| dc.date.accessioned | 2023-12-05T10:22:04Z | |
| dc.date.available | 2023-12-05T10:22:04Z | |
| dc.date.issued | 2017-09-01 | |
| dc.description.abstract | Background/Objectives: Germ cell tumors (GCT) account for 2-3% of childhood tumors. It is most commonly seen under 3 years and over 12 years old. GCTs are most commonly localized in the gonads. We have examined our patients who diagnosed and treated with GCT at our center retrospectively. Design/Methods: Sixty two children and adolescence who were diagnosed and treated with GCT at our center between 1996 and 2016 analyzed retrospectively. Results: The patients age ranged between 5 days to 17 years. Thirty-five of patients were girls (57%) and 27 were boys (43%). The most common tumor localization with 29(47%) patients was gonads. Sixteen patients (25,8%) had metastatic disease at presentation. The most common histologic subtype was mature teratoma with 14 (22%) patients and 14 patients (22%) with yolk sac tumor. Alpha-fetoprotein (AFP) was elevated in 29 (46%) of cases whereas beta-human chorionic gonadotropin (𝛽-hCG) was elevated in only 4 (4%) of cases. Twenty-two cases (35%) were treated with total surgical resection and they didn't receive chemotherapy. Six patients (10%) received radiotherapy in addition to surgery and chemotherapy. Thirty-three patients (53,3 %) received BEP (bleomycin, etoposide, cisplatin) as a first line chemotherapy. During the follow up 6 (10 %) patients had relapsed. Five years overall survival rate of our patients was 95%, retrospectively. Conclusions: Germ cell tumors have favorable outcome in children. These tumors can be cured with surgical resection followed by cisplatin-based chemotherapy and radiotherapy for selected patients. As a result of our own data analysis, it has been found that our survival rates are similar to current literature data. | |
| dc.identifier.citation | ŞENAY R. E., DOĞRU Ö., TOKUÇ A. G., EKER N., YILMAZ B., BERK B., \"Twenty Years’ Experience in the Management of Childhood Germ Cell Tumors\", 49th CONGRESS OF THE INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY (SIOP), Amerika Birleşik Devletleri, 12 Ekim 2017 | |
| dc.identifier.startpage | 460 | |
| dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/pbc.26772 | |
| dc.identifier.uri | https://hdl.handle.net/11424/295391 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | 49th CONGRESS OF THE INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY (SIOP) | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.title | Twenty years’ experience in the management of childhood germ cell tumors | |
| dc.type | conferenceObject | |
| dspace.entity.type | Publication | |
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