Publication: Prediction of subclinical left ventricular dysfunction by speckle-tracking echocardiography in patients with anti-neutrophil cytoplasmic antibody--associated vasculitis
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2021-12-24
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Abstract
Objectives: This study aims to evaluate left ventricular functions using speckle-tracking echocardiography (STE) in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Patients and methods: Between June 2018 and July 2019, a total of 31 AAV patients (17 males, 14 females; median age: 53 years; range, 47 to 62 years) and 21 healthy controls (11 males, 10 females; median age: 56 years; range, 46 to 60 years) were included in the study. Clinical and biochemical characteristics of all participants were recorded. All participants underwent conventional and two-dimensional STE. The receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off value of serum N-terminal prohormone of brain natriuretic peptide (NT-pro-BNP) that predicted subclinical left ventricular dysfunction. The Spearman correlation analysis was used to determine the correlation between left ventricular global longitudinal strain (LV-GLS) and NT-pro-BNP. Results: The LV-GLS was lower in AAV patients (19.3% vs. 21.7%, respectively; p=0.014). NT-pro-BNP was negatively correlated with LV-GLS (p=0.005, r=0.401). Conclusion: Subclinical left ventricular dysfunction can be detected by STE in patients with AAV who have free of clinically overt cardiovascular disease. The LV-GLS is negatively correlated with serum NT-pro-BNP levels.
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Tıp, Sağlık Bilimleri, Dahili Tıp Bilimleri, İç Hastalıkları, İmmünoloji ve Romatoloji, Medicine, Health Sciences, Internal Medicine Sciences, Internal Diseases, Immunology and Rheumatology, ROMATOLOJİ, Klinik Tıp, Klinik Tıp (MED), RHEUMATOLOGY, CLINICAL MEDICINE, Clinical Medicine (MED), Romatoloji, Rheumatology, Anti-neutrophil cytoplasmic antibody-associated vasculitis, cardiovascular risk, speckle-tracking echocardiography, strain, LEFT ATRIAL VOLUME, INFLAMMATION, ATHEROSCLEROSIS, GRANULOMATOSIS, STRAIN, : Anti-neutrophil cytoplasmic antibody-associated vasculitis, cardiovascular risk, speckle-tracking echocardiography, strain
Citation
Izgi T. N., Atas D., ATAŞ H., Akaslan D., Ilgin C., VELİOĞLU A., ARIKAN İ. H., Alibaz-Oner F., DİRESKENELİ R. H., TUĞLULAR Z. S., et al., "Prediction of subclinical left ventricular dysfunction by speckle-tracking echocardiography in patients with anti-neutrophil cytoplasmic antibody--associated vasculitis.", Archives of rheumatology, cilt.37, sa.1, ss.129-135, 2021