Person: ALKAN, ELİF
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Publication Metadata only Effect of the use of remineralization agents before resin infiltration on the treatment of initial enamel lesions: OCT, ultrasound, and SEM evaluation(2023-06-11) MANAV, AYBİKE; DOĞU KAYA, BENGÜ; YILMAZ ATALI, PINAR; ALKAN, ELİF; TAĞTEKİN, DİLEK; MANAV ÖZEN A., DOĞU KAYA B., YILMAZ ATALI P., SARIALİOĞLU GÜNGÖR A., ALKAN E., DALKILIÇ E., TAĞTEKİN D., TÜRKMEN C.Aim: It was aimed to investigate the effect of using remineralizing agent before resin infiltration application on the treatment of initial enamel lesions with OCT (Optical Coherence Tomography), Ultrasound and SEM (Scanning Electromicroscope). Materials and Methods: 80 enamel samples were kept in the demineralization solution (pH 4.5, 37°C) for 96 hours. Demineralized enamel samples will be randomly divided into 8 groups (n=10) including a remineralizing agent(Toothmousse/GC, Remin Pro/VOCO, Medical Mineral Gel/ROCS), resin infiltration (ICON/DMG), and a combined treatment of both. All remineralization agents were applied in remineralization cycle 2 times a day for 1 week.Measurements made from the enamel samples at the baseline, after demineralization and remineralization procedures evaluated with the OCT (Topcon3D OCT-1 Maestro) and ultrasonic system (Novascope 4500:NDT) lesion depths were measured. The sample surfaces were examined under SEM/EDS (Zeiss EVO-MA10) at x1000, 2500, 5000 and 10000. Data were analyzed in R program with WRS2. Two-way Robust Anova, Benferroni Test, and ICC (Intra-Class Correlation Coefficient) was used to examine the agreement between measurements. Significance level was set at p<0.05. Results: There was no statistical difference between the groups in OCT (p=0.884) and Ultrasound (p=0.051) median values after the protocols. In both measurement methods, the effect of remineralization treatments was statistically significant for lession depth (p<0.01). OCT median values were 104.01 in baseline, 144.78 in post-demineralization, and 90.5 in post-remineralization. Ultrasound median values were 1.34 in baseline, 1.1 in postdemineralization, and 2.36 inpost-remineralization. The highest ultrasound median value was obtained in the Remin Pro+ICON after remineralization (2.67), while the lowest value was obtained after demineralization (1.04). As a result of EDS analysis, the lowest Ca ratio (%atomic) was observed on the grup 5-ICON applied enamel surface (9.35). Conclusion: Although there is no significant difference between the groups, all groups were found efficient for remineralization treatments according to OCT, Ultrasound, and SEM/EDS analysis.Publication Open Access Evaluating the effects of different remineralization agents on initial enamel lesions in vitro(2022-04-23) ALKAN, ELİF; YILMAZ ATALI, PINAR; TAĞTEKİN, DİLEK; SARIALİOĞLU GÜNGÖR A., DALKILIÇ E., ALKAN E., YILMAZ ATALI P., TAĞTEKİN D.Aim: Disruption of the demineralization–remineralization balance could activate the development of initial enamel lesions. Extrinsic assistance is needed to remineralize enamel lesions. The aim of this study was to evaluate the efects of fuoride varnish, enamel matrix proteins derivative, and experimental bioactive glass (BAG) on remineralization of initial enamel lesions in vitro. Materials and Methods: Artifcial initial caries lesions were developed on ffty human enamel samples using demineralization solution (pH 4.5, 37°C, 96 hours). Samples were randomly assigned to 5 groups (n=10): I-Fluoride varnish (Enamelast), II-Experimental BAG + 37% phosphoric acid (PA), III-Enamel matrix proteins derivative (EMPD, Emdogain) +Ethylenediamine-Tetraacetic-Acid (EDTA), IVEMPD+37% PA, V-Control (untreated). All remineralization agents were applied with pH cycling for 7 days. The samples were scanned by optical coherence tomography (OCT) at baseline, demineralization, and after pH cycling. Lesion depths were measured using image analysis software (ImageJ). Lesions were evaluated using surface microhardness (SMH) and two fuorescence methods (FluoreCam® and DIAGNOdent Pen (DDPen)). The data were statistically analyzed by Kruskal Wallis, Friedman, and Wilcoxon tests (p<0.05). Results: According to OCT results, fuoride varnish was found to be the most efective agent in reducing lesion depth (p=0.005). Depending on SMH results, all agents increased the surface hardness values after pH cycling. No signifcant diference was found among fuoride varnish, BAG, and EMPD+PA groups. And these microhardness values were signifcantly higher than EMPD+EDTA and control groups (p<0.001). According to the DDPen score criteria, all groups showed lower scores compared with the control group (p<0.001), however, Clinical Oral Investigations (2022) 26:7299–7348 7317 1 3 no signifcant diference was found among the remineralization agent groups. In FluoreCam assessment, size and intensity values of all treated groups showed improvement. However, there was no signifcant diference between the treatment groups in terms of FluoreCam-size measurements (p=0.186). Conclusion: BAG and EMPD+PA has a remineralization capacity as much as fuoride varnish. EMPD+PA showed better microhardness and lesion intensity results than EMPD+EDTA.Publication Open Access Evaluation of the Effect of Different Remineralizing Agents and Ozone Application on Artificial Carises(2024-01-01) ALKAN, ELİF; TAĞTEKİN, DİLEK; Erçin Ö., Kopuz D., ALKAN E., TAĞTEKİN D., Yanikoğlu F.This study aimed to assess the combined and individual effects of different remineralization agents and ozone application on initial caries. Seventy-two premolar teeth were collected. Three different toothpastes (Ipana, ROCS, and Gumgumix) were utilized. The samples were divided into eight groups (n = 8) for experimentation (Distilled water, Ipana+Ozone, Gumgumix+Ozone, ROCS +Ozone, Ipana, Gumgumix, ROCS, Ozone). Microhardness measurements were conducted initially. All samples were then immersed in a demineralization solution for 72 hours to induce initial caries. Then, microhardness measurements were repeated, and pH cycles were carried out for one-week. Finally, microhardness measurements and SEM-EDS analyses were performed. Ipana+Ozone exhibited the highest microhardness value, which was statistically significant compared to other groups except ROCS+Ozone (p < 0.05). Distilled water, Gumgumix+Ozone, and Gumgumix displayed the lowest microhardness values. Ozone application with remineralization agents led to higher precipitation of Ca ions. The demineralized group showed the lowest Ca, P, and F ions. While Ipana +Ozone and ROCS+Ozone had the highest Ca ions, Gumgumix+Ozone had the highest P ions. Within the study’s limitations, it can be concluded that ozone gas positively impacts the remineralization process in initial caries lesions. Additionally, mineral-containing products demonstrated a noteworthy capacity to reverse the demineralization process.